How do you approach postoperative radiation therapy in a patient with head and neck cancer who has high risk of recurrence in the setting of active epidermolysis bullosa?

Epidermolysis bullosa is a rare genetic entity characterized by collagen mutations affecting the attachment of epithelial cells to the basement membrane of the skin and mucosa, manifesting in blistering and non-healing skin wounds and mucosal strictures in the GI tract. There is a risk of non-healin...

There is unfortunately little information on radiation treatment in EB. It really depends on what type of EB they have and what type of cancer. For example, if they have recessive dystrophic EB (RDEB) and squamous cell carcinoma, this needs to be treated aggressively, and may not be a good candidate...