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How do you approach symptom control in a patient with diffuse cutaneous systemic sclerosis (dcSSc) and rapidly progressive skin disease?   

Relatively newly diagnosed RNA Pol 3+ dcSSc with rapidly progressive skin involvement now on methotrexate 20mg/week and tocilizumab for concurrent inflammatory arthritis, but with significant discomfort and pain due to ongoing skin tightening which has been refractory to topical emollients and pain control with tramadol.



Answer from: at Academic Institution
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