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How do you approach symptom control in a patient with diffuse cutaneous systemic sclerosis (dcSSc) and rapidly progressive skin disease?   

Relatively newly diagnosed RNA Pol 3+ dcSSc with rapidly progressive skin involvement now on methotrexate 20mg/week and tocilizumab for concurrent inflammatory arthritis, but with significant discomfort and pain due to ongoing skin tightening which has been refractory to topical emollients and pain control with tramadol.



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