How do you decide to choose TC vs CMF for HER2 negative breast cancer patients who warrant adjuvant chemotherapy?  

There are various modifications of CMF. Most of the data on the efficacy of CMF is based on the "classic" dose and scheduling, i.e. IV MTX and 5-FU on day 1 and 8, and oral cyclophosphamide on day 1-14 of a 28-day cycle. [Historically, this regimen was developed to duplicate the schedule of the high...

I agree.  I choose TC.  However, if my patient has a severe reaction to Docetaxel, my practice is to administer CMF.