How do you manage a patient with low risk MDS who achieves transfusion independence with luspatercept but continues to have fatigue?

Is there a role for increasing the dose if not yet maximum? (Hb ~8)

Answer from: Medical Oncologist at Community Practice

This is a challenging question and I'm not sure there's clear data to support a practice one way or another. Anecdotally, I have noticed that when using Luspatercept, it seems to improve hemoglobin reliably and therefore lead to less transfusions, but I have not observed a consistent concordant impr...

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Medical Oncologist at Providence Hospital and Medical Centers
I had a similar situation and changed to imtelstat...

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How do you manage a patient with low risk MDS who achieves transfusion independence with luspatercept but continues to have fatigue?

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