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Topics:
Radiation Oncology • Neuro-Oncology
How do you manage a recurrent anaplastic meningioma?
What dose/volumes would you recommend for a previously radiated tumor not amenable to surgical resection?
Answer from: Radiation Oncologist at Community Practice
(This answer was formulated in conjunction with @Dheerendra Prasad)Unfortunately, this is a very common occurrence for these uncommon, aggressive histology tumors. In our own institution's review of patients with pathologically confirmed grade 2 and 3 meningiomas, 2/3 recurred at a median time of ~2...
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Answer from: Radiation Oncologist at Academic Institution
In general, the prognosis of recurrent anaplastic meningioma after previous surgery and radiation is poor. I usually try to persuade my neuro-oncology colleague to use bevacizumab and everolimus first, based on the paper in Journal of neuro-oncology 129: 281-288, 2016, that reported a median PFS of ...