How do you manage a supraclavicular only recurrence in NSCLC previously treated with chemoradiation for Stage III disease?  

If the patient is otherwise fit and wishes to pursue aggressive therapy, I would consider definitive dose radiation therapy either as consolidation after systemic therapy, or concurrent with systemic therapy.While any recurrence of lung cancer is often a harbinger of systemic progression, a minority...

A supraclavicular only recurrence after previous chemoRT for Stage III NSCLC is rare, occurring in approximately 7% of cases. I would treat it with palliative radiation alone, to be followed by systemic therapy (chemotherapy, chemo-IO, or IO alone, depending on circumstances). The dose would depend ...

If this is truly the only site of disease, and sufficiently far away from prior radiation field with a decent disease-free interval, one could certainly consider an oligometastatic treatment paradigm.   I have treated situations like this with 25Gy to the PTV with simultaneously integrated bo...