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How do you manage PSA progression while a patient is on xofigo or pluvicto?
If a patient has clinical or biochemical progression while on either of these radiopharmaceuticals, would you stop the treatment or continue?
Answer from: Radiation Oncologist at Community Practice
The tl;drPSA is very much an imperfect tool for these patients. The data show that PSA may initially increase over multiple cycles before decreasing, though this is a minority of patients. Most patients whose PSA increases early have resistant disease, and you should investigate further with imaging...
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