How do you sequence therapy in an older patient with newly-diagnosed blastoid mantle cell lymphoma with a 17p deletion?  

Tricky question. There are two issues, 1. the morphology and 2. depending on how you evaluate a 17p deletion. The deletion in literature isn't as clearly associated with poor outcomes as compared to mutations. Given that there are two copies, as long as one allele is still present then would still h...