How does age factor into your planning whether to give a high risk pre-menopausal patient with breast cancer ovarian function suppression?  

Generally, my age cutoff is 50, but it depends on the patient’s documented menopausal status prior to chemotherapy. If the patient is perimenopausal, then I initiate ovarian suppression plus aromatase inhibitor and check estradiol and FSH every 12 months. When she is clearly post-menopausal, t...

Presumably, for someone at high risk of disease recurrence, she will have received chemotherapy. In that setting, if the woman was premenopausal at the time of chemotherapy initiation and developed amenorrhea, one needs to be quite cautious up to at least age 50 if starting AI plus OFS because of th...