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Topics:
Radiation Oncology • Thoracic Malignancies
How does neoadjuvant chemo-immunotherapy impact your decision on hypofractionation/dose-fractionation for locally advance NSCLC now getting RT alone?
Is 60 Gy/15 fx appropriate? Is there a volume PTV cut-off cc which would switch to a more fractionated approach (60 Gy/30 fx eg)? Is there an area you would dose reduce (e.g., hilum or mediastinum) after neoadj chemo-immunotx?
Answer from: Radiation Oncologist at Academic Institution
I still try for 60 Gy in 15 fractions if radiation alone, though I will dose adjust based on my OARs and at times underdose the PTV to maybe 52.5 Gy and try for 60 Gy to the ITV
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