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How is ESR used in the clinical staging/risk classification of classical Hodgkin Lymphoma in pediatric and adult patients?
The current NCCN guideline version 2.2021 is a little confusing. On page HODG-2, the clinical staging/risk classification did not include ESR, but on page HODG-4 and HODG-B, it says "NCCN Unfavorable Factors include bulky mediastinal or >10 cm disease, B symptoms or ESR>=50, and > 3 sites of disease."
Answer from: at Community Practice
There has not been a consistent initial risk classifier for childhood Hodgkin Lymphoma (in contrast to the IPS used in adults). ESR has been used to follow patients in terms of a trend if elevated at diagnosis and that continues to be suggested by the current pediatric guidelines. Schwartz et al., (...
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