How many days do you hold osimertinib during or around SBRT for oligometastatic EGFR mutated advanced lung cancer?
Does the site of treatment factor into your decision?
Answer from: Medical Oncologist at Academic Institution
This a great question and a common clinical scenario that we are all confronted with. Stereotactic body radiation therapy (SBRT) is being increasingly used for oligometastatic progression of EGFR mutant NSCLC. The theoretical risk of combining EGFR inhibitors and radiation therapy would be an enhanc...
Comments
Radiation Oncologist at Mount Carmel Medical Center Agree, the original protocol of the SINDAS study (...
Radiation Oncologist at National Cancer Centre Singapore Anything that goes beyond 3 weeks is a bit worriso...
Answer from: Radiation Oncologist at Academic Institution
As far as I know, there is not a clear answer for this situation. After discussion with our medical oncology team, we currently tend to hold osimertinib for about 5-7 days prior to and after RT based on a similar logic as Dr. @Afshin Dowlati above. Anecdotally, even after holding osimerti...
Comments
Medical Oncologist at MD Anderson Cancer Center at Cooper - Camden Any reason to hold osimertinib if RT is given to p...
Agree, the original protocol of the SINDAS study (...
Anything that goes beyond 3 weeks is a bit worriso...