How many days do you hold osimertinib during or around SBRT for oligometastatic EGFR mutated advanced lung cancer?   

This a great question and a common clinical scenario that we are all confronted with. Stereotactic body radiation therapy (SBRT) is being increasingly used for oligometastatic progression of EGFR mutant NSCLC. The theoretical risk of combining EGFR inhibitors and radiation therapy would be an enhanc...

As far as I know, there is not a clear answer for this situation. After discussion with our medical oncology team, we currently tend to hold osimertinib for about 5-7 days prior to and after RT based on a similar logic as Dr. @Afshin Dowlati above.  Anecdotally, even after holding osimerti...