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How would you approach a high grade neuroendocrine carcinoma found in a mediastinal lymph node with unknown primary?
Would you treat this AP window node like small cell lung cancer with chemoRT?
Answer from: Radiation Oncologist at Academic Institution
If it showed the histopathological signs of a small cell lung cancer (TTF1, Synaptophysin, Chromogranin positive, high-grade), then yes. Assuming PET/CT and diagnostic CT chest are both negative for other sites of disease? Could consider EBUS in attempt to identify additional potential addition...
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Answer from: Radiation Oncologist at Community Practice
If this does not appear to be "Small Cell Lung Cancer", then one option may be to perform concurrent chest radiotherapy with chemotherapy using the "Locoregional, unresectable" pathway of the "Extrapulmonary Poorly Differentiated" Category of the "Neuroendocrine and Adrenal Tumors Guideline" as a st...