How would you approach a patient with ER+,HER2- T4N0 breast cancer with chest wall involvement?  

In a patient with locally advanced ER positive HER2 negative breast cancer, requiring neoadjuvant therapy, I would use third generation chemotherapy such as AC followed by paclitaxel (often in a dose dense fashion), as long as there are no contraindication to anthracycline based regimen. This EBCTCG...