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How would you approach a T1N1 NSCLC with a small peripheral primary tumor and single hilar node in a patient not fit for concurrent chemo or surgery?

Would you offer SBRT to both sites, SBRT to the primary and standard fractionation to the node due to proximity to the main bronchus/proximal lobar bronchus? Would your recommendation change for a patient previously treated with SBRT for a peripheral tumor at least 2 years prior? What about SCLC?
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How do you treat T1/2N1 NSCLC in patients not fit for concurrent chemo or surgery?

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1 Answer
Mednet Member
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Radiation Oncology · Yale School of Medicine
Answered on

If the patient were not a candidate for surgery or chemotherapy, then I would favor hypofractionated radiotherapy to 60 Gy in 15 fractions to both the primary and the hilar lymph node based on UTSW phase I data. If the patient may be a candidate for immunotherapy, then I would strongly consider enro...

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