How would you approach adjuvant therapy for large (≥4 cm), node negative, HR+, HER2- breast cancer in an elderly woman with comorbidities including neuropathy?  

If multiple co-morbidities are present in an elderly patient with locally advanced HR+/HER2- breast cancer that precludes anthracycline and taxane chemotherapy regimen, then I would consider 2 options: (1) CMF regimen which is active and generally well tolerated (one can also consider upfront dose r...

Why not more detail? What is elderly mean here? Does the patient have a greater than 5-year expected survival? If not then I would use endocrine therapy alone. I also would not give chemotherapy without an Oncotype for node-negative disease that is T3.