How would you approach local therapy (surgery or RT) in a patient with radiographic complete response after chemoimmunotherapy for non-small-cell lung cancer?

Would you consider omitting local therapy?

Answer from: Radiation Oncologist at Academic Institution

Only 1/96 patients (0.6%) of patients on CheckMate 816 had a complete response by RECIST so I don't think our current paradigms are really driving these kinds of responses. Additionally, there is clearly a disconnect between clinical response rates by RECIST (0.6%) and pathologic complete response (...

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Radiation Oncologist at UCLA | VA Greater Los Angeles Healthcare System
A negative preop ctDNA test, even if highly sensit...

Answer from: Radiation Oncologist at Academic Institution

So many good answers here already. I do get asked this frequently by my residents, so giving a short educational answer about "how I do it" might add a bit to these replies. Firstly, the patient should get surgery if they are a candidate and willing to undergo resection. The data for inductio...

Answer from: Radiation Oncologist at Academic Institution

It’s hard to envision a scenario with CR. No residual scar tissue. Full dose RT or resection.

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Radiation Oncologist at Kings County Hospital Center
True. Truly, complete cure is not possible without...

Radiation Oncologist at Northwestern Medical Group
In terms of target delineation, would you target a...

Radiation Oncologist at University of Kansas Medical Center
Yes. The targets should be pre-neoadjuvant tumor s...

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How would you approach local therapy (surgery or RT) in a patient with radiographic complete response after chemoimmunotherapy for non-small-cell lung cancer?

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