How would you approach local therapy (surgery or RT) in a patient with radiographic complete response after chemoimmunotherapy for non-small-cell lung cancer?

Would you consider omitting local therapy?

Answer from: Radiation Oncologist at Academic Institution

Only 1/96 patients (0.6%) of patients on CheckMate 816 had a complete response by RECIST so I don't think our current paradigms are really driving these kinds of responses. Additionally, there is clearly a disconnect between clinical response rates by RECIST (0.6%) and pathologic complete response (...

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Radiation Oncologist at UCLA | VA Greater Los Angeles Healthcare System
A negative preop ctDNA test, even if highly sensit...

Answer from: Radiation Oncologist at Academic Institution

It’s hard to envision a scenario with CR. No residual scar tissue. Full dose RT or resection.

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Radiation Oncologist at Kings County Hospital Center
True. Truly, complete cure is not possible without...

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How would you approach local therapy (surgery or RT) in a patient with radiographic complete response after chemoimmunotherapy for non-small-cell lung cancer?

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