How would you approach treatment of DLBCL in a patient on hemodialysis?

How would you handle high risk features (eg double hit) with the limitations of dialysis?

Answer from: Medical Oncologist at Academic Institution

For R- CHOP based therapy it can be administered the day before dialysis with no dose adjustments. Only Cyclophosphamide has renal clearance and should be reduced by 50%. For more aggressive regimens it becomes more challenging as there is not enough data. This is what we would consider doing...

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Medical Oncologist at NYU Winthrop Hospital
Thanks for your guidance in this difficult situati...

Answer from: Medical Oncologist at Community Practice

For elderly patient on HD R-mini CHOP day before HD is feasible.

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How would you approach treatment of DLBCL in a patient on hemodialysis?

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