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How would you manage a patient with newly diagnosed synchronous triple positive and metaplastic triple negative breast cancers?
For early stage disease in a single breast, would you consider neoadjuvant chemotherapy or upfront surgical staging followed by adjuvant therapy? What would be your chemotherapy/HR/Her2 agents of choice?
Answer from: Medical Oncologist at Academic Institution
Aside from considerations about genetic testing given the dual primaries, and local therapy considerations which I would defer to surgery and rad onc, this case would raise the question of which (neo)adjuvant regimens to consider. I would assess the risk for both cancer independently, and then attem...
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Answer from: Medical Oncologist at Academic Institution
Even though metaplastic triple negative breast cancers are felt to be relatively chemo-resistant, responses are seen in the neoadjuvant setting and we typically recommend standard chemotherapy in these cases as we cannot clearly exclude a benefit as would be seen in other triple negative cases. ...