How would you manage acquired von Willebrand syndrome secondary to a myeloproliferative neoplasm in a patient who is already on anticoagulation?

Individuals with MPNs may be at higher risk for thrombosis and be placed on antiplatelet therapy or even anticoagulation because of prior thrombosis. How do you approach the anticoagulation of these same patients if they develop an acquired von Willebrand syndrome?

Answer from: at Academic Institution

Acquired von Willebrand activity is something that can occur with MPN patients. It should be part of routine testing of patients with both ET and PV. Although, historically, usually thought of as a phenomenon of when platelets are greater than 1000, a recent publication (Rottenstreich et al., PMID 2...

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How would you manage acquired von Willebrand syndrome secondary to a myeloproliferative neoplasm in a patient who is already on anticoagulation?

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