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Hematologic Malignancies • Lymphoma • NCI-CCC Tumor Board Question • Internal Medicine • Hematology • UC Irvine • NCI-CCC Lymphoma Tumor Board Question
How would you manage biopsy-proven DLBCL in a patient who was treated with 6 cycles of R-CHOP 15 years ago for DLBCL?
Would you consider this de novo DLBCL (unable to assess for clonality)? How would you handle prior anthracycline exposure?
Answer from: Medical Oncologist at Academic Institution
It will be difficult to tell if this is a relapse vs. de novo DLBCL unless you have the old pathology slides available and if a skilled pathologist is able to tell. In general, patients with late relapses > 24 months from achieving remission have favorable outcomes with salvage chemotherapy and a...
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