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How would you manage refractory psoriatic arthritis now well-controlled on upadacitinib in a current smoker with a history of melanoma and who recently developed an unprovoked pulmonary embolism, now on apixaban?

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How would you manage refractory psoriatic arthritis now well-controlled on upadacitinib in a current smoker with a history of melanoma and who recently developed an unprovoked pulmonary embolism, now on apixaban? | Mednet