How would you treat an older patient with newly diagnosed B-ALL and significant cardiac and neurological co-morbidities?  

Treating older patients with newly diagnosed B-ALL WITHOUT significant comorbidities is challenging enough! There is no accepted standard of care for the treatment of older adults with ALL, typically defined as over the age of 60. Lower intensity chemotherapy backbones with the addition of ABL kin...

I agree with @Ryan D. Cassaday that the treatment of older (>60 yrs) patients with ALL is challenging! I would add that in addition to the CALGB9111 regimen, there is a lower intensity backbone that was developed by the European Working Group for Adult ALL (EWALL). This regimen starts with a...