How would you treat patient with a stage IV lung adenocarcinoma, an exon 21 p.H835L mutation, high TMB, and negative PD-L1?  

EGFR H835L mutation is a rare variant that is in Ex21 of EGFR. Though there is not a lot of data with this particular mutation, the available data suggest that it is a sensitizing mutation with a few case reports suggesting that patients harboring these mutations have a good outcome with EGFR TKI. T...