In a patient with history of recurrent VTE despite anticoagulation, would you consider lenalidomide as part of your initial myeloma regimen?  

I would still consider lenalidomide as part of the initial myeloma regimen provided that they were on therapeutic dose anticoagulation (my preference is apixaban 5 mg BID or rivaroxaban 20 mg daily). Ideally, this would be started at least 3 months after therapeutic dose anticoagulation for the most...

It's interesting that the IMID's prothrombotic effects can often be mitigated by aspirin, potentially because of platelet reactivity even though this is controversial. IMiDs double the risk of arterial clots (CVAs and MIs) and triple the risk of venous thrombi, making me wonder if the most effe...