In a patient with stage III NSCLC who was treated with neoadjuvant systemic therapy and had a PR, would you deliver RT to all sites of initially involved disease, or only residual sites of disease?

E.g. If a patient had CR in the primary tumor but PR in the nodes, would you still treat the primary?

Answer from: Radiation Oncologist at Academic Institution

I struggle with this one quite often. The data would suggest that you need to treat all initial sites, but of course, that's not the purpose of those studies (defining what sites, dose to sites, etc) and there's almost assuredly something going on with that aspect of the therapy. The other way to th...

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Radiation Oncologist at Cancer Center at Lake Manassas
That was a very thoughtful summary. Thank you!

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In a patient with stage III NSCLC who was treated with neoadjuvant systemic therapy and had a PR, would you deliver RT to all sites of initially involved disease, or only residual sites of disease?

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