In contemplating neoadjuvant RT, how would you manage a large, non-RT-induced angiosarcoma of the right breast in a young female?

Would you consider post-operative adjuvant treatment more favorable? Does resectability influence your decision? Would grade of the tumor affect your approach? Any further data/concerns beyond those previously presented (https://www.themednet.org/question/4066)?

Answer from: Medical Oncologist at Academic Institution

I would have her get a mastectomy first. 1. You want your surgeons in their comfort zones. Preop treatment of any sort is a discussion to have with her surgeon in advance of doing anything. Breast surgeons who see 99.9% adenocarcinoma are used to preop chemo but n...

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Radiation Oncologist at Fox Chase Cancer Center
Thank you Dr. Read for your wonderful points.

Answer from: Radiation Oncologist at Academic Institution

Multiple approaches possible. We have tended to offer neoadjuvant radiation therapy as upfront mastectomy can often lead to positive margins. While different RT techniques exist we have utilized neoadjuvant RT alone (BID or TID) followed by mastectomy. 4 cm around all gross disease. W...

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Radiation Oncologist at Varian Medical Systems/Allegheny health network
Our approach for RT naive is surgery if operable t...

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In contemplating neoadjuvant RT, how would you manage a large, non-RT-induced angiosarcoma of the right breast in a young female?

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