In what scenarios would you incorporate platinum for patients with localized TNBC?  

In the neoadjuvant setting, I include a platinum - specifically carboplatin - in the chemo regimen in essentially all patients with TNBC. Not only have 3 randomized studies (CALGB 40603, BrighTNess and GeparSixto) demonstrated significantly higher pCR rates with addition of carboplatin, if you look ...

@William M. Sikov has thoughtfully presented an evidence based case for incorporating platinum in the management of localized TNBC. However, I believe incorporation of platinum in the management of localized TNBC remains controversial and should be individualized and reserved for patients with the h...

On the question of identifying biomarkers for response to platinum, neither germline/tumor BRCA status, nor identifiers of BRCANess like HRD assay have been shown to be conclusive. The BrighTNess and GeparSixto studies reported no significant interactions between BRCA mutation status and treatment ...