Is 10 Gy x 5 an acceptable dose to use for lung SBRT in tumors with favorable location (eg. not central and not encroaching on the chest wall?)

Given the multiple retrospective studies showing benefit to higher BED fractionation schedules (most recently, http://www.redjournal.org/article/S0360-3016(17)34044-0/fulltext), should 10 Gy x 5 ever be considered acceptable (assuming favorable location)?

Answer from: Radiation Oncologist at Academic Institution

The paper cited, which my colleague Kevin Stephans authored, used our large institutional data base with long term follow up to carry out a retrospective review of BED adjusted SBRT schedules and showed no difference in overall survival, but slightly improved local control, with higher BED schedules...

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Radiation Oncologist at Abramson Cancer Center, University of Pennsylvania
this is another great paper from the Cleveland cli...

Answer from: Radiation Oncologist at Academic Institution

I agree except that for favourably located tumours, I still use 18Gy X3. For locations near the ribs, near main airways I will use 10GyX5 if I cannot meet the restraints based on protocols. Size matters. Bigger the mass, the higher the dose we need as demonstrated by the long term data from Japan th...

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Is 10 Gy x 5 an acceptable dose to use for lung SBRT in tumors with favorable location (eg. not central and not encroaching on the chest wall?)

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