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Is concurrent intrathecal therapy necessary with HD-MTX for CNS lymphoma?
How do you determine whether to add intrathecal chemotherapy in patients with +CSF? Would your approach change for primary vs secondary CNS lymphoma?
Answer from: Medical Oncologist at Community Practice
Generally, high dose methotrexate has high penetration into the CSF so you do not need to give concurrent intrathecal therapy. The only time you might consider it is if they still have persistent disease in the CSF despite the high dose methotrexate. The approach does not change for primary vs secon...
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