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Breast Cancer • Radiation Oncology
Is it acceptable to offer 26 Gy in 5 fractions for APBI rather than whole-breast RT?
For patients who are otherwise eligible for CALGB 9343 and candidates for APBI who choose to proceed with partial breast RT, are you offering 26 Gy in 5 fractions?
Answer from: Radiation Oncologist at Community Practice
I think it is reasonable and in low-risk populations, we do offer especially if dosimetric constraints are difficult with 30 in 5.
Answer from: Radiation Oncologist at Academic Institution
This fractionation is being studied on the ACCEL clinical trial (link below). But it begs the question, why is this fractionation scheme currently being considered when you have multiple other high-quality PBI regimens with very low toxicity already supported by Phase III evidence? Quirk et al....
Answer from: Radiation Oncologist at Community Practice
The Florence trial publication preceded the UK Fast Forward publication by five years. Hence, the lower dose in the latter study becomes of interest when using the APBI technique from the former. This is only to be expected as we are always striving to find the least effective dose even when the hig...
Logically, this approach makes sense, but why expo...
I was not clear - not treating the whole breast. ...
Thank you for the clarification @Simul Parikh, thi...
This brings up some very good points and a broader...
That was quite trenchant Dr. @Parikh. Thank you.&n...
Terrific post @Simul Parikh. The link to the OPAL-...
Thank you, @Robert. I appreciate the kind words.&n...