Is it appropriate to consider biologic therapy for treatment of RA in a patient with non-small cell lung carcinoma treated with radiation therapy, who has ongoing active synovitis uncontrolled by conventional DMARDs?   

Yes, active RA needs to be treated, and starting biologics should be considered after failing conventional DMARDs; there is no contraindication to the use of biologic in patients with previously treated solid malignancies like lung cancer as per 2015 ACR guidelines. The new 2020 guidelines are to be...