Please select the option that best describes you:
Is it safe to irradiate a patient with Cowden syndrome?
In an asymptomatic patient, would this be safe?
Is there any reason to withhold radiation such as in the case of T1N0 breast cancer advising the patient to not do breast conservation but instead get a mastectomy?
I’ve only found two case reports - one in which this was very toxic Tatebe et al., IJROBP 2017
And the other in which no mention of toxicity is made (Chandhanayingyong et al., PMID 26553762). Wondering if anyone knows of other series or has personal experience in terms of toxicity, tolerance, and potential late effects.
Answer from: Radiation Oncologist at Community Practice
I irradiated 1 patient with breast cancer and Cowden syndrome about 25-30 years ago and she tolerated it well without any unusual early or late toxicity
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Answer from: Radiation Oncologist at Academic Institution
I irradiated a patient with Cowden Syndrome last year and she developed profound fatigue from radiation, so much so that we had to stop treatment.
Answer from: Radiation Oncologist at Community Practice
I have never done it for limited data and concern for toxicities.