Is there a role for Elacestrant in ER+ metastatic breast cancer with ESR1-YAP1 fusion on NGS?

It depends on the specific details of the fusion protein and where the fusion breakpoint is. Also, the clonality of the fusion may play a role too. There are reports of a stable in-frame ESR1 e6 YAP1 fusion protein that has the ESR1 DNA binding/nuclear localization domains but the ligand binding dom...