Is there a role of adjuvant or systemic therapy for patients with resected stage I colon cancer with subsequent local recurrence S/P a second resection and now has NED?   

Tough question. Depending on the numbers, there is literature to suggest 5% recurrence and also in some ctDNA series of similar numbers have recurrence.In general, it would not be unreasonable to offer some systemic. However, the decision to consider that would be in the context of: Clinical detail...