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Mov Disord Clin Pract 2022 Oct 23

Clozapine Is Severely Underused in Parkinson's Disease Patients.

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Is it possible to develop worsening motor features of Parkinson's disease (PD) when using clozapine (for treatment of PD psychosis) above a certain dose?

1 Answers
Mednet Member
Mednet Member
Neurology · Columbia University Medical Center

Clozapine does not appear to worsen Parkinson's disease at most doses used for patients with PD. Other side effects are dose limiting such as orthostatic hypotension and sedation. The challenge of blood monitoring has limited the use of this drug in the US.There is a wonderful podcast on movementdis...