Given the critical role that diagnostic radiology has in patient care, it is important for providers and patients to understand the level of certainty associated with imaging. Over-reliance on imaging and failure to appreciate its limitations can lead to unforeseen consequences. Further, there are uncertainties and inconsistencies in the manner in which imaging-based information is considered, communicated, and applied. There are opportunities to alter practice to maximize comprehension of radiologic reports and thus optimize the manner in which imaging-based information is applied clinically.