Buspirone was compared with imipramine and placebo in the treatment of panic disorder in an 8-week, double-blind controlled study of 52 randomly assigned patients. The side effect profile of buspirone was less disruptive than that of imipramine. Buspirone was not significantly superior to placebo in its antipanic or anxiolytic effects in panic disorder patients.
From the beginning, it was mentioned that buspirone was ineffective or seemed so for patients previously on benzodiazepines. I believe this is true, but it is primarily becaus...