International journal of radiation oncology, biology, physics 2018-01-06
Radiation Dose-Volume Effects for Liver SBRT.
ABSTRACT
Stereotactic body radiation therapy (SBRT) has emerged as an effective, noninvasive treatment option for primary liver cancer and metastatic disease occurring in the liver. Although SBRT can be highly effective for establishing local control in hepatic malignancies, a tradeoff exists between tumor control and normal tissue complications. The objective of the present study was to review the normal tissue dose-volume effects for SBRT-induced liver and gastrointestinal toxicities and derive normal tissue complication probability models.
Related Questions
Liver SBRT maintaining 700 ccs of liver <15 Gy is a commonly used constrain; however, if the total liver volume is limited due to cirrhosis, prior ...
New comment by Radiation Oncologist at Medical College of Wisconsin ( December 8, 2020)
This response makes a lot of sense, thank you. The 700 cc's comes from a conservative approach to trying to spare 25%-35% of a typical liver volume (2000 cc's). Despite knowin...
Is there a role for re-irradiation? What cumulative dose constraints do you use for re-irradiation to the central hepatobiliary tract?
New answer by Radiation Oncologist at Mayo Clinic School of Medicine (April 22, 2021)
This is a challenging scenario for which there is no quick/easy solution. My initial assessment would involve obtaining a further understanding of the patient’s performa...