Muscle & nerve 2013-04
Striational antibodies in a paraneoplastic context.
ABSTRACT
INTRODUCTION
The clinical significance of striational antibodies (StrAbs) detected in the course of paraneoplastic antibody testing is unknown.
METHODS
We compared all 203 striational antibody (StrAb)-seropositive patients identified (2004-2005) during evaluation for paraneoplastic antibodies with age- and sex-matched seronegative controls.
RESULTS
Thymoma and myasthenia gravis (MG) were significantly more common among cases (P<0.0001). Cancers more rarely detected after StrAb detection were adenocarcinoma in 5 patients and sarcoma in 3 patients. All patients who had a cancer identified after StrAb testing had a titer of ≥ 1:7680 or a coexisting muscle AChR-binding antibody. Autoimmune disorders more commonly observed among cases (with any StrAb value) included: hypothyroidism; rheumatoid arthritis; and pernicious anemia (all P<0.05).
CONCLUSIONS
StrAbs may serve as a diagnostic clue for an autoimmune diagnosis. There is a low likelihood of oncological significance in patients with StrAb titers <1:7680 without coexisting paraneoplastic Abs.
Related Questions
For example, a GAD65 Ab of 0.07 when the cut-off is 0.02. Does this answer change if you consider adult vs pediatric populations?
New answer by at University of Kentucky (August 18, 2022)
Antibody levels can fluctuate; therefore, I don’t think there’s one good answer. If one goes with clinical symptomatology and follows the patient clinically, it mi...