Clin Transl Radiat Oncol 2017 Nov 21
SYSTEMS-2: A randomised phase II study of radiotherapy dose escalation for pain control in malignant pleural mesothelioma.
ABSTRACT
SYSTEMS-2 is a randomised study of radiotherapy dose escalation for pain control in 112 patients with malignant pleural mesothelioma (MPM). Standard palliative (20 Gy/5#) or dose escalated treatment (36 Gy/6#) will be delivered using advanced radiotherapy techniques and pain responses will be compared at week 5. Data will guide optimal palliative radiotherapy in MPM.
Related Questions
E.g. right hemithorax disease from lung apex to diaphragm, no response s/p 3 cycles of cis/pem.
New answer by Medical Oncologist at West Virginia University Cancer Institute (October 8, 2021)
In addition to radiation option, immunotherapy can be tried as well.