Treatment De-intensification for HPV-Positive Oropharynx Cancer: What Is Currently Acceptable?

Mednet Member

Radiation Oncology · University of Texas MD Anderson Cancer Center

This is a very complex question, as the issues of dose, and de-escalation can be difficult to sum up in an hour lecture let alone a Mednet query. Personally, for me, efforts to lessen volume and doses to subclinical disease are a bit more interesting.Quoting Cmelak et al., PMID 34043410 (2021) in an...

Mednet Member

Radiation Oncology · Mayo Clinic

I am going to write specifically on de-escalating HPV-OPSCC in the adjuvant setting first, important caveats for adjuvant de-escalation, and then about the general philosophy on de-escalation in clinical trials.Concerning adjuvant treatment, after careful consent, we are de-escalating patients with ...