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Breast Cancer • Medical Oncology
Should ovarian suppression be recommended to premenopausal ER/PR positive patients?
A recent publication of the TEXT and SOFT trials http://www.ncbi.nlm.nih.gov/pubmed/27044936 showed an improvement in breast cancer-free interval with the addition of ovarian suppression in women with high recurrence risk. What clinicopathological features would you consider? What method would you recommend for ovarian suppression?
Answer from: Medical Oncologist at Academic Institution
The SOFT trial (https://www.ncbi.nlm.nih.gov/pubmed/25495490) found an improvement in DFS for combined ovarian suppression + AI compared to tamoxifen alone (the OA + Tam group was intermediate). While the overall results were positive, I think putting the results in practice requires looking at the ...
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