What adjuvant therapy would you offer following adjuvant chemotherapy for a patient with Stage III lung adenocarcinoma with an atypical EGFR mutation such as EGFR L861R?
Would you offer adjuvant atezolizumab, osimertinib, or neither? Both IMpower010 and ADAURA only had patients with EGFR exon 19 deletion or L858R mutations.
Answer from: Medical Oncologist at Academic Institution
Mutations at position 861 (most commonly L861Q) have been described, occurring in approximately 2% of all EGFR-mutant patients [Mitsudomi and Yatabe, PMID 19922469]. These mutations are considered partially sensitizing to afatinib based on a post-hoc analysis of LUX-Lung 2, LUX-Lung 3, and LUX-Lung ...
Comments
Medical Oncologist at Blue Ridge Cancer Care Thank you very much Dr. @Tejas Patil for your...
Medical Oncologist at Onc San Antonio Dr. @Tejas Patil, would you offer adjuvant Atezo i...
Medical Oncologist at University of Colorado I would not offer adjuvant atezolizumab to EGFRm N...
Medical Oncologist at Onc San Antonio Thank you Dr. @Patil for your insight and I a...
Medical Oncologist at Los Angeles VA Medical Center Yes, Dr. @Navneet Mittal, a common scenario and a ...
Medical Oncologist at University of Colorado There is data on EGFRm NSCLC who received durvalum...
Medical Oncologist at Onc San Antonio Thank you Dr. @Anthony Bejjani for directing me to...
Thank you very much Dr. @Tejas Patil for your...
Dr. @Tejas Patil, would you offer adjuvant Atezo i...
I would not offer adjuvant atezolizumab to EGFRm N...
Thank you Dr. @Patil for your insight and I a...
Yes, Dr. @Navneet Mittal, a common scenario and a ...
There is data on EGFRm NSCLC who received durvalum...
Thank you Dr. @Anthony Bejjani for directing me to...