theMednetRegister

Please select the option that best describes you:

Topics: Breast Cancer • Medical Oncology • Breast Cancer, Non-metastatic

What adjuvant therapy would you recommend for a premenopausal woman with low ER+/PR+ (1-10%) HER2- pT1cN0 metaplastic breast cancer?  

Does the low ER+ or metaplastic histology affect your recommendations?



Answer from: Medical Oncologist at Academic Institution
The rarity of the metaplastic subtype of breast cancer makes it difficult to provide an evidence-based answer regarding what is the "best" adjuvant treatment. About 70% of metaplastic tumors are TNBC and ER-low is a small subset of the remaining 20% with an ER+ epithelial component. In general, some...
Comments
Medical Oncologist at NYU Winthrop Hospital
Excellent review, Dr. @Soliman.
Sign in or Register to read more
Answer from: Medical Oncologist at Academic Institution
While I agree with Dr. @Soliman that I would recommend that this patient receive adjuvant chemotherapy and that I would treat her as having triple-negative disease, as I would a patient with an ER-low invasive ductal carcinoma, I would definitely treat her with weekly paclitaxel and carboplatin, as ...
Comments
Medical Oncologist at START Center for Cancer Care
Metaplastic TNBC has poor response to anthracyclin...
Medical Oncologist
Just to clarify, you would treat this as TNBC but ...
Medical Oncologist at Warren Alpert Medical School of Brown University
Yes, I would not administer immunotherapy with or ...
Medical Oncologist at H Lee Moffitt Cancer Center, University of South Florida
There isn't a large amount of data on pembrolizuma...
Sign in or Register to read more
Copyright © 2025 theMednet
All Rights Reserved.