What are the factors that convince you to not immediately treat mantle cell lymphoma and to follow a course of "active surveillance"?  

A subset of patients with MCL have a significantly longer survival (often more than 7-10 years) and a more indolent disease course. Two separate groups have reported patients who did not receive up-front chemotherapy at the time of diagnosis but were instead actively monitored, t...

There are two generalized populations of patients with Mantle Cell Lymphoma that I will choose “active surveillance” or observation without immediate treatment. The first is patients with leukemic non-nodal mantle cell lymphoma who are asymptomatic. These patients often are diagnosed aft...

In general, the patients I consider observation in have low Ki67%<30% which is a cutoff often used to separate patients in terms of prognosis. Most often, these patients have a Ki67% of 10% or less along with a limited disease burden (e.g. no significant adenopathy, peripheral blood involvement)....