What are your thoughts on the relevance of sentinel lymph node biopsy before the onset of neoadjuvant chemotherapy for HER2+ or triple negative cT2+N0M0 breast cancer patients?

Nodal staging changes radiation fields, but given increasing pertinent null findings of a positive SLNBx with regards to outcomes, I wonder if ypN0 is the most important prognostic indicator - an indicator that would be lost if SLNB was done pre-chemo.

Answer from: Radiation Oncologist at Community Practice

We don’t favor SNLN bx upfront as systemic agent is the same for the two phenotypes for T2 and the above disease and will tailor the RT field based on the final pathology.

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What are your thoughts on the relevance of sentinel lymph node biopsy before the onset of neoadjuvant chemotherapy for HER2+ or triple negative cT2+N0M0 breast cancer patients?

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