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What dose and fields would you use to treat a low grade CNS lymphoma that presents as an isolated single mass in the brain?
The patient has a history of a lymphoplasmacytic lymphoma with a CR after chemotherapy but presented with a large frontal lobe mass that was biopsied revealing a low grade lymphoma. Would you treat the tumor only with ISRT concepts or treat the whole brain? Would you recommend chemotherapy or radiation as the first line treatment in this scenario?
Answer from: Radiation Oncologist at Academic Institution
De novo presentations of low-grade lymphomas in the brain parenchyma are very, very rare. Suppose a patient had a relatively small, well-localized, low-grade NHL such as FL or MZL in the brain parenchyma, without any evidence of disease elsewhere (negative PET-CT, bone marrow biopsy, etc.). In that ...
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Answer from: Radiation Oncologist at Academic Institution
Lymphoplasmacytic lymphoma is an extremely rare neoplasm with an annual incidence of 3 to 4 cases per million people. It represents approximately two percent of all hematologic malignancies. Lymphoplasmacytic lymphoma is also a disease of elderly individuals in the seventh and eighth decade of life,...