What dose constraint do you use for the proximal bronchial tree for when treating NSCLC to 60 Gy/8 fx?
I see the LungTECH trial dose constraints, but, they seem really conservative when you have something large and close the PBT resulting in use of 60 Gy/ 8 fx.
Answer from: Radiation Oncologist at Academic Institution
The Canadian LUSTRE trial (which randomizes patients to 48/4 or 60/8 versus 60/15) accepts a dose limit of 64 Gy max, and 60 Gy to 5 cc to the PBT for a 60/8 fractionation schedule. Typically we aim to keep the dose relatively less heterogeneous within the target so as not to draw any significant ho...
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Radiation Oncologist at Lake Huron Medical Center This is interesting.
The 70/10 data from MD...
Radiation Oncologist at McMaster University School of Medicine Interesting you ask...the data from LUSTRE that wa...
Answer from: Radiation Oncologist at Academic Institution
A very helpful reference based on UK consensus for normal tissue constraints when considering 3, 5, 8 # SABR
https://www.clinicaloncologyonline.net/article/S0936-6555(17)30434-X/pdf
Note that there will always be the dilemma - prioritize OAR vs. PTV? I think the issue is nuanced and comes down to ...
This is interesting. The 70/10 data from MD...
Interesting you ask...the data from LUSTRE that wa...