What dose constraint do you use for the proximal bronchial tree for when treating NSCLC to 60 Gy/8 fx?

I see the LungTECH trial dose constraints, but, they seem really conservative when you have something large and close the PBT resulting in use of 60 Gy/ 8 fx.

Answer from: Radiation Oncologist at Community Practice

The Canadian LUSTRE trial (which randomizes patients to 48/4 or 60/8 versus 60/15) accepts a dose limit of 64 Gy max, and 60 Gy to 5 cc to the PBT for a 60/8 fractionation schedule. Typically we aim to keep the dose relatively less heterogeneous within the target so as not to draw any significant ho...

Comments

Radiation Oncologist at Lake Huron Medical Center
This is interesting. The 70/10 data from MD...

Radiation Oncologist at McMaster University School of Medicine
Interesting you ask...the data from LUSTRE that wa...

Answer from: Radiation Oncologist at Academic Institution

A very helpful reference based on UK consensus for normal tissue constraints when considering 3, 5, 8 # SABR https://www.clinicaloncologyonline.net/article/S0936-6555(17)30434-X/pdf Note that there will always be the dilemma - prioritize OAR vs. PTV? I think the issue is nuanced and comes down to ...

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What dose constraint do you use for the proximal bronchial tree for when treating NSCLC to 60 Gy/8 fx?

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