What dose do you use for single fraction SBRT when treating a small, peripheral early stage NSCLC?

There have been two randomized phase II studies of single fraction versus multi-fraction lung SBRT for medically inoperable early stage lung cancer patients. In RTOG 0915, 82% of patients were T1. In the Roswell Park Cancer Institute study, 86% of patients were stage IA. With that in mind, the curre...

Will echo Dr. @Dr. First Last's comments.

We treat exclusively with 34 Gy in 1 fx to all non-central lung tumors. Previously treated 27 Gy in 1 fx. While the initial trial was with 30 Gy, that was without heterogeneity correction so the delivered dose was likely 27 Gy to the periphery with het correc...

The Stanford iSABR international phase II trial used an individualized volume, location, and histology adapted SABR dosing regimen.

Out of 285 treated tumors, 159 were small (GTV<10cc), peripheral tumors that were prescribed 25 Gy single fraction per protocol. 5-year treated tumor recurrence rate was...

Interesting question and to be honest, I have only done a few cases of single fraction SBRT and tend to favor the 3-5 fraction approach but in the cases I have done it, I go to 34 Gy based on RTOG 0915. If I am not able to meet an OAR, then I would consider fractionating to 3-5 and not underdosing m...